خاکشیر: گیاهشناسی، خواص و توصیه‌های قبل از مصرف

1. Diana Quiroz, D. (2018). Descurainia sophia (flixweed). CABI Invasive Species Compendium Datasheet. Retrieved from https://www.researchgate.net/323258117

2. Mohamed, N.H., & Mahrous, A.E. (2009). Chemical constituents of Descurainia sophia L. and its biological activity.  Records of Natural Products, 3(1), 58-67. Retrieved from https://www.acgpubs.org/RNP-0811-54.pdf

3. Mahdavi Ara, K., Jowkarderis, M., & Raofie, F. (2015). Optimization of supercritical fluid extraction of essential oils and fatty acids from flixweed (Descurainia Sophia L.) seed using response surface methodology and central composite design. Journal of Food Science and Technology, 52(7), 4450 - 4458. Retrieved from https://www.ncbi.nlm.nih.gov/PMC4486533/

4. Nimrouzi, M., & Zarshenas, M.M. (2016). Phytochemical and pharmacological aspects of Descurainia sophia Webb ex Prantl: modern and traditional applications. Avicenna Journal of Phytomedicine, 6(3), 266–272. Retrieved from https://www.ncbi.nlm.nih.gov/PMC4930533/

5. Klein, H. (2011). Flixweed, Descurainia sophia (L.) Webb ex Prantl. Retrieved from https://accs.uaa.alaska.edu/wp-content/

6. Mitich, L.W. (1996). Flixweed (Descurainia sophia). Weed Technology, 10(4), 974-977. Retrieved from https://ucanr.edu/repository/167426

7. Ayoobi, F., Kamali, B., Shamsizadeh, A., Sajadi, M.A., Roohbakhsh, A., Vazirinejad, R., …   Allahtavakili, M. (2013). Effect of aqueous extract of Descurainia sophia on castor oil-induced diarrhea in male rat. Journal of Rafsanjan University of Medical Sciences, 12(2), 149-56. [Farsi]. Retrieved from http://journal.rums.ac.ir/

8. Pasalar, M., Lankarani, K.B., Mehrabani, D., Tolide-i, H.R., & Naseri, M. (2013). The effect of Descureania sophia L. and Prunus domestica L. in prevention of constipation among Iranian hajj pilgrims, Saudi Arabia. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 4(2), 1195 – 1204. Retrieved from http://research.shahed.ac.ir/1111282212

9. Nimrouzi, M., Sadeghpour, O., Imanieh, M.H., Ardekani, M.S., Salehi, A., Minaei, M.B., & Zarshenas, M.M. (2015). Flixweed vs. polyethylene glycol in the treatment of childhood functional constipation: a randomized clinical trial. Iranian Journal of Pediatrics, 25(2), e425. Retrieved from https://www.ncbi.nlm.nih.gov/PMC4506010

10. Hsieh, P.C., Kuo, C.Y., Lee, Y.H., Wu, Y.K., Yang, M.C., Tzeng, I.S., & Lan, C.C. (2020).  Therapeutic effects and mechanisms of actions of Descurainia sophia. International Journal of Medical Sciences, 17(14), 2163-2170. Retrieved from https://www.medsci.org/v17p2163.htm

11. Pourmasoumi, M., Ghiasvand, R., Darvishi, L., Hadi, A., Bahreini, N., & Keshavarzpour, Z. (2019). Comparison and assessment of flixweed and fig effects on irritable bowel syndrome with predominant constipation: a single-blind randomized clinical trial. EXPLORE,15(3), 198-205. Retrieved from https://www.sciencedirect.com/S1550830718301873

12. Baek, S.J., Chun, J.M., Kang, T.W., Seo, Y.S., Kim, S.B., Seong, B., … Kim, C. (2018). Identification of epigenetic mechanisms involved in the anti-asthmatic effects of Descurainia sophia seed extract based on a multi-omics approach. Molecules, 23(11), 2879. Retrieved from https://www.ncbi.nlm.nih.gov/PMC6278437/

13. Lu, H., Fu, Z., Chen, X., Yang, M., Chen, Y., & Yang, L. (2022). Shegan mahuang decoction may reduce airway inflammation in neutrophilic asthmatic mice by improving the mitochondrial function of bronchoalveolar lavage fluid exosome. Evidence-Based Complementary and Alternative Medicine, vol.  2022, Article ID 2477510, 8 pages. Retrieved from https://downloads.hindawi.com/2022/2477510

14. Gong, J., Zhang, Y., He, J., Zheng, X., Feng, W., Wang, X., … Cao, Y. (2015). Extractions of oil from Descurainia sophia seed using supercritical CO₂, chemical compositions by GC-MS and evaluation of the anti-tussive, expectorant and anti-asthmatic activities. Molecules, 20(7), 13296–13312. Retrieved from https://www.ncbi.nlm.nih.gov/PMC6332279/

15. Luo, Y., Sun, Z., Hu, P., Wu, Y., Yu, W., Huang, S. (2018). Effect of Aqueous Extract from Descurainia sophia (L.) Webb ex Prantl on Ventricular Remodeling in Chronic Heart Failure Rats. vol. 2018, Article ID 1904081, 8 pages. Retrieved from https://www.hindawi.com/2018/1904081/

16. Moshaie-Nezhad, P., Bahari, Z., Jangravi, Z., Zarei, S.M., & Iman, M. (2021). The effect of Descurainia sophia seed extract on nephrotoxicity markers induced by acetaminophen in mice. Journal of Advances in Medical and Biomedical Research, 29(134), 139-144. Retrieved from https://www.researchgate.net/350560063

17. Asgharpour, M., Enayati, N., Sadrabadi, M.R., Afrakati, M.M., Khavandegar, A., Mardi, P., … Bakhtiyari, M. (2022). Effects of Descurainia sophia on oxidative stress markers and thirst alleviation in hemodialysis patients: a randomized double-blinded placebo-controlled cross-over clinical trial. Evidence-Based Complementary and Alternative Medicine, vol. 2022, Article ID 2001441, 12 pages. Retrieved from https://www.hindawi.com/2022/2001441/

18. Saremi, J., Hasheminasab, M., Sadeghi, N., & Jahromi, H. (2018). Preventive and curative effects of aqueous extracts of Descurainia sophia L. on nephrolithiasis induced in rats. Asian Journal of Pharmaceutics, 12(1), S228-S233. Retrieved from https://www.researchgate.net/328573941

19. Moshaie-Nezhad, P., Iman, M., Maleki, F.F., & Khamesipour, A. (2018). Hepatoprotective effect of Descurainia sophia seed extract against paracetamol-induced oxidative stress and hepatic damage in mice. Journal of Herbmed Pharmacology, 7(4), 267-272. Retrieved from http://herbmedpharmacol.com/jhp-1304

20. Sadeghi, M., Borujeni, F.E., Ghodsi, S., & Moshtaghian, J. (2021). Investigating the effect of hydroalcoholic extract of Descurainia sophia(L.) Webb ex Prantl on blood glucose, biochemistry parameters, fatty profile, and serology factor in diabetic male rats. International Journal of Health and Life Sciences (IJHLS), 7(3), e115280. Retrieved from https://brieflands.com/jhrt-115280.pdf

21. Nejati, V., & Khaneshi, F. (2014). The effect of hydroalcoholic extract of Descurainia sophia seed on the changes of testis tissue, sperm parameters, and testosterone level in rats with streptozotocin-induced diabetes. Qom University of Medical Sciences Journal, 8(5), 26-33. Retrieved from https://pesquisa.bvsalud.org/emr-160329

22. Abed, D.Z., Jabbari, S., Zakaria, Z.A., & Mohammadi, S. (2022). Insight into the possible mechanism(s) involved in the antinociceptive and antineuropathic activity of Descurainia sophia L. Webb ex Prantl essential oil. Journal of Ethnopharmacology, 298, 115638. Retrieved from https://www.sciencedirect.com/S0378874122006778

23. Luo, M., Zhou, L., Huang, Z., Li, B., Nice, E.C., Xu, J., & Huang, C. (2022). Antioxidant Therapy in Cancer: Rationale and Progress. Antioxidants, 11(6), 1128. Retrieved from https://www.mdpi.com/2076-3921

24. Shahidi, B., Sharifi, A., Nasiraie, L.R., Niakousari, M., & Ahmadi, M. (2020). Phenolic content and antioxidant activity of flixweed (Descurainia sophia) seeds extracts: Ranking extraction systems based on fuzzy logic method. Sustainable Chemistry and Pharmacy, 16, 100245. Retrieved from https://www.sciencedirect.com/S2352554120300085

25. Khodarahmi, E., Asghari, G.H., Hassanzadeh, F., Mirian, M., & Khodarahmi, G.A. (2015). Cytotoxic evaluation of volatile oil from Descurainia sophia seeds on MCF-7 and HeLa cell lines. Research in Pharmaceutical Sciences, 10(2), 169–176. Retrieved from https://www.ncbi.nlm.nih.gov/PMC4584456/

26. Park, J.S., Lim, C.J., Bang, O.S., & Kim, N.S. (2016). Ethanolic extract of Descurainia sophia seeds sensitizes A549 human lung cancer cells to TRAIL cytotoxicity by upregulating death receptors. BMC Complementary and Alternative Medicine, 16, 115. Retrieved from https://link.springer.com/s12906-016-1094-0

27. Lee, Y.J., Kim, N.S., Kim, H., Yi, J.M., Oh, S.M., Bang, O.S., & Lee, J. (2013). Cytotoxic and anti-inflammatory constituents from the seeds of Descurainia sophia. Archives of Pharmacal Research, 36, 536–541. Retrieved from https://link.springer.com/s12272-013-0066-x

28. Afsharypour, S., & Haery, A. (1989). Effect of glucosinolate autolysis products on rat serum T3 and T4 concentrations. Medical Journal of the Islamic Republic of Iran, 3 (3-4), 165-168. Retrieved from https://mjiri.iums.ac.ir/1-1584-en

29. Rahman, M.J., Ambigaipalan, P., & Shahidi, F. (2018). Biological activities of camelina and sophia seeds phenolics: inhibition of LDL oxidation, DNA damage, and pancreatic lipase and α-glucosidase activities. Journal of Food Science, 83(1), 237-245. Retrieved from https://www.researchgate.net/327040459

30. Ghasemi Dehkordi, N., Sajadi, S., Ghanadi, A., Amanzadeh, Y., Azadbakht, M., Asghari, G.R., … Tale, A.M. Iranian herbal pharmacopoeia. Ministry of Health Pub Tehran. 2002; 1:105. [Persian].

31. Bussmann, R.W., Batsatsashvili, K., Kikvidze, Z., Paniagua-Zambrana, N.Y., Khutsishvili, M., Nasab, F.K., … Tchelidze, D. (2020). Descurainia sophia (L.) Webb ex Prantl Brassicaceae. Ethnobotany of the Mountain Regions of Far Eastern Europe, 379–38. Retrieved from https://link.springer.com/10.1007

32. Hadi-Nezhad, M., Rowland, O., & Hosseinian, F. (2015). The Fatty Acid Profile and Phenolic Composition of Descurainia sophia Seeds Extracted by Supercritical CO₂. Journal of the American Oil Chemists' Society, 92, 1379–1390. Retrieved from https://link.springer.com/s11746-015-2693-5

33. Ngo, N.T.T., & Shahidi, F. (2021). Functional properties of protein isolates from camelina (Camelina sativa (L.) Crantz) and flixweed (sophia, Descurainis sophia L.) seed meals. Food Production, Processing and Nutrition, 3, 31. Retrieved from https://fppn.biomedcentral.com/10.1186

34. Nabimeybodi, R., Meyari, A., Vahiddastjerdi, M., Hajimehdipoor, H., Ghasemi, E., Bioos, S., & Tansa, M. (2018). The Effect of Flixweed-Honey Vaginal Product on Cervicitis: a Clinical Trial. Research Journal of Pharmacognosy (RJP), 5(2), 41-49. Retrieved from https://www.rjpharmacognosy.ir/58506

 35. Flixweed seeds benefits in traditional medicine. Retrieved from https://www.naturalremediest.com/flixweed-seeds-benefits

36. Bagheri, H., Saki, S., Jafari, A., Naderi, R., & Deljou, A. (2019). Investigation of phenotypic and molecular diversity of Descurainia sophia (L.) Webb ex Prantl and Sisymbrium irio (L.). Agriculturae Conspectus Scientificus, 84(2), 179-188. Retrieved from https://hrcak.srce.hr/file/323728

37. Shakeri, T., Yousofpour, M., & Azadbakht, M. (2017). Comparative study of Flixweed properties from the perspective of traditional medicine scientists. Complementary Medicine Journal, 3(24). [FARSI]. Retrieved from http://cmja.arakmu.ac.ir/1-484-fa

38. Yi, J.M., Kim, Y.A., Lee, Y.J., Bang, O.S., & Kim, N.S. (2015). Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro. BMC Complementary and Alternative Medicine, 15, 441. Retrieved from https://www.ncbi.nlm.nih.gov/PMC4683934/

39. Behbahani, M.S., & Abbasi, S. (2017). Stabilization of flixweed seeds (Descurainia sophia L.) drink: Persian refreshing drink. Food Bioscience, 18, 22-27. Retrieved from https://www.sciencedirect.com/S221242921730072X